Jamestown Hotel Near I-94 & Buffalo Museum Located along Interstate 94 in the middle of North Dakota, is the Holiday Inn Express® - Jamestown, ND. If you're looking for business-friendly hotels in Jamestown, North Dakota, look no further. We're near Cargill, Cavendish Farms, Goodrich, the University of Jamestown, and Jamestown Regional Medical Center. Our 558 square foot business center offers your business a convenient location for a meeting or social function. Our free high speed internet and business center keep you and your business connected when you are in Jamestown. Travelers looking for a more leisurely pace will find both indoor and outdoor attractions located only minutes from the hotel. These attractions include the World’s Largest Buffalo, the National Buffalo Museum and two rare albino buffalo settled in the historic Frontier Village. If you are an outdoor enthusiast, explore 30 miles of biking/hiking trails or the Jamestown Reservoir. Whether your stay is for business or leisure, the Holiday Inn Express – Jamestown has all the amenities you expect from the Holiday Inn Express brand. After a restful night’s sleep, enjoy our free Express Start Breakfast featuring a wide variety of favorite breakfast items.